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Ketamine’s antidepressant effects appear unrelated to stress hormones, study finds

Summary by PsyPost
A study of individuals with treatment-resistant depression found that hormones associated with the hypothalamic-pituitary-adrenal (HPA) axis do not influence the antidepressant effects of ketamine. However, individuals with longer-lasting depressive episodes tended to have lower levels of adrenocorticotropic hormone (ACTH) and corticotropin-releasing factor (CRF). The research was published in the Journal of Affective Disorders. The HPA axis is …

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PsyPost broke the news in on Thursday, May 15, 2025.
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