JCI Patient-derived xenograft models of Fanconi anemia–associated head and neck cancer identify personalized therapeutic strategies

JCI Patient-derived xenograft models of Fanconi anemia–associated head and neck cancer identify personalized therapeutic strategies

Fanconi anemia (FA) confers a high risk (~700-fold increase) of solid tumor formation, most often head and neck squamous cell carcinoma (HNSCC). FA germline DNA repair defects preclude administration of most chemotherapies, and prior hematopoietic stem cell transplantation limits the use of immunotherapy. Thus, surgery and judicious delivery of radiation offer the only treatment options, with most patients dying from their cancers. A paucity of …