JCI Multiple sclerosis–associated CD226 variant disrupts vitamin D–induced type I Treg differentiation by impairing LFA-1 activation

JCI Multiple sclerosis–associated CD226 variant disrupts vitamin D–induced type I Treg differentiation by impairing LFA-1 activation

Multiple sclerosis (MS) is a complex inflammatory disease of the CNS resulting from an intricate interplay between genetic predisposition and environmental factors. Vitamin D (VD) deficiency is one of the established risk factors for MS. CD46 costimulation of CD4+ T cells induces a switch from Th1 to type I regulatory cells (Tr1), characterized by increased IL-10 production. This switch is impaired in MS T cells but can be restored by VD, which …