Type 2 Diabetes and Brain Health Are Linked in Older Adults From Various Populations

Type 2 diabetes and brain health are linked in older adults from various populations

A new USC-led study has uncovered a significant link between type 2 diabetes mellitus and cortical thickness in older adults from various populations.

USC Study Uncovers Connection Between Type 2 Diabetes and Brain Health in

A groundbreaking study led by researchers at the University of Southern California (USC) has revealed a compelling connection between type 2 diabetes mellitus (T2DM) and reduced cortical thickness in the brains of older adults across diverse ethnic groups. This research provides critical insight into how chronic metabolic disorders can affect brain morphology, potentially accelerating age-related cognitive decline. Published in the prestigious j…

JCI AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes

Growing evidence suggests that the pathogenesis of type 2 diabetes (T2D) involves dysfunctional central mechanisms, and, hence, the brain can be targeted to treat this disease. As an example, a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) can normalize hyperglycemia for weeks or months in rodent models of T2D. Convergent evidence implicates inhibition of a particular subset of neurons as a mediator of this …