Isolated Gut Microbe Drives Stronger Responses to Cancer Therapy
JAPAN, JUL 16 – The newly discovered gut bacterium YB328 activates immune cells to improve cancer immunotherapy, which currently benefits only about 20% of patients long term, researchers said.
7 Articles
7 Articles
Isolated gut microbe drives stronger responses to cancer therapy
The National Cancer Center Research Institute in Tokyo reports that a newly isolated gut bacterium, designated Hominenteromicrobium strain YB328, mobilizes specialized dendritic cells to strengthen the impact of PD-1 blockade immunotherapy across several tumor types.
Japanese scientists have discovered intestinal bacteria that increase the effectiveness of cancer drugs: how they work - Global Happenings
A group of researchers from Japan found that a certain strain of intestinal bacteria increases the efficiency of cancer immunotherapy. This showed an experiment using mice. Researchers from the National Oncological Center of Japan and other organizations published their conclusions in the scientific journal Nature. Scientists analyzed the feces of 50 patients with cancer who were undergoing immunotherapy. Patients who responded well to therapy w…


Genomic Study Uncovers Diverse Carbohydrate Use in Bifidobacteria
In a groundbreaking study published in Nature Microbiology, an international team of researchers led by Arzamasov, Rodionov, and Hibberd has unveiled unprecedented insights into the genetic and functional diversity of carbohydrate metabolism among human gut bifidobacteria. This research leverages cutting-edge integrative genomic reconstruction methodologies to dissect the heterogeneous strategies these prominent gut microbes employ to utilize di…
Researchers have identified an intestinal bacterial strain that amplifies the effects of immune control point inhibitors, a type of anti-cancerous therapies. The strain stimulates the activity of dendritic cells, which in turn redirect and concentrate T-cells to tumours. This would explain the differences in responses to treatment in patients and paves the way for new strategies based on intestinal microbiota. Treatments mobilizing the immune sy…
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