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Isolated Gut Microbe Drives Stronger Responses to Cancer Therapy

JAPAN, JUL 16 – The newly discovered gut bacterium YB328 activates immune cells to improve cancer immunotherapy, which currently benefits only about 20% of patients long term, researchers said.

Summary by Medical Xpress
The National Cancer Center Research Institute in Tokyo reports that a newly isolated gut bacterium, designated Hominenteromicrobium strain YB328, mobilizes specialized dendritic cells to strengthen the impact of PD-1 blockade immunotherapy across several tumor types.

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Researchers have identified an intestinal bacterial strain that amplifies the effects of immune control point inhibitors, a type of anti-cancerous therapies. The strain stimulates the activity of dendritic cells, which in turn redirect and concentrate T-cells to tumours. This would explain the differences in responses to treatment in patients and paves the way for new strategies based on intestinal microbiota. Treatments mobilizing the immune sy…

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Trust My Science broke the news in on Tuesday, July 15, 2025.
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