US EditionCould a Gene Lower Nicotine Dependence? What a CHRNB3 Variant Suggests
A rare CHRNB3 gene variant linked to 21% to 78% reduced cigarette consumption was identified across Indigenous Mexican, European, and East Asian populations, highlighting new nicotine addiction drug targets.
7 Articles
7 Articles
Could a gene lower nicotine dependence? What a CHRNB3 variant suggests
Variants in a nicotine receptor gene are associated with a lower likelihood of heavy smoking, according to a study published in Nature Communications. The findings are based on data from populations in Mexico and validated in populations with Asian and European ancestries.
People who carry certain genetic variants involved in the regulation of nicotine are less likely to smoke in an intense way. These are the...
For decades, public health has been waging a relentless battle against smoking. Smoking kills seven million people in the world every year, its countless harmful effects are known at the end, but addiction is so powerful that once it starts, leaving it can end up being an odyssey. There are treatments to fight smoking, but therapeutic options are limited and science continues to look for new strategies to help cut that dependence that generates …
These findings were observed mainly in Mexican population data, although the same effects were confirmed in mutations of people with Asian and European ancestry. “Acetylcholine receptors are proteins that bind to nicotine in the brain and trigger changes in behavior, pleasure sensations and the degree of addiction of smokers” explains to SINC the first author of the work and researcher of the Regeneron Genetics Center (USA), Veera Rajagopa. In t…
According to a study, those carrying a variant of a nicotine receptor gene would smoke up to 78% fewer cigarettes than those carrying the current version. Based on data collected from thousands of people of various origins, these variants were significantly associated with a lower probability of smoking behaviour, and could potentially be promising therapeutic targets against smoking addiction. Smoking is one of the leading causes of death in th…
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