Injection turns sleeping tumor immune cells into cancer fighters
KAIST's injectable lipid-nanoparticle therapy reprograms tumor macrophages into CAR-macrophages, showing strong cancer-killing effects and stimulating immune response in animal models.
7 Articles
7 Articles
Researchers Discover New Way To Wake Up Cancer-Killing T Cells
A new multi-pronged antibody design could help immune cells receive stronger activation signals against cancer. Researchers at the University of Southampton have identified a new strategy that could strengthen how the immune system responds to cancer. Reporting their findings in Nature Communications, the scientists describe the use of specially engineered antibodies designed to more effectively [...]
Injection turns sleeping tumor immune cells into cancer fighters
KAIST researchers have developed a way to reprogram immune cells already inside tumors into cancer-killing machines. A drug injected directly into the tumor is absorbed by macrophages, prompting them to recognize and attack cancer cells while activating nearby immune defenses. This eliminates the need for lab-based cell extraction and modification. In animal models, the strategy significantly slowed tumor growth and sparked strong anticancer imm…
Enhanced Tumor Immunotherapy via Targeted Nanoparticles
In recent years, enhancing cancer immunotherapy has emerged as one of the leading fields of research in oncology. The emergence of novel therapeutic agents designed to remodel the tumor microenvironment is pivotal for overcoming tumor resistance mechanisms and improving overall therapeutic efficacy. A groundbreaking study by Li et al. has taken significant strides towards this goal, revealing the transformative impacts of utilizing hyaluronidase…
An important scientific breakthrough opens a new door to hope in the fight against cancer. Researchers at the University of Southampton have designed in the laboratory a superprotein capable of enhancing the immune system so that it is the one that identifies and destroys tumor cells with an efficacy never seen before.This finding, published in the prestigious journal Nature Communications, could radically change the focus of today's immunothera…
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