Stanford Transplants Lab-Grown Human Brain Tissue into Mice
The human grafts grew larger, formed functional neural networks and affected memory and motor behavior, researchers said.
- On Wednesday, Stanford University neuroscientists published a study in Nature describing a new method for growing human brain organoids inside genetically engineered mice.
- Previous attempts failed because rodent cells outcompeted human grafts; neuroscientist Sergiu Pașca and his Stanford University team solved this by engineering mice lacking specific cerebral cortex and hippocampus structures.
- In 25 of 29 attempts, human tissue filled more than 90% of the vacant space, forming specialized neurons including rare von Economo cells never before grown in a dish.
- These chimeric animals provide a platform to study cerebral palsy and frontotemporal dementia; Pașca noted human cortical cells appear to restore lost functions in the grafted mice.
- Experts like Nita Farahany of Duke Law emphasize ethical caution as the team deliberately halted experiments before human cells formed consciousness markers, noting this work "brings us into new gray areas.
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128 Articles
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Stanford Scientists Create Mice With Half-Human Brains
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Stanford researchers successfully grow human brain tissue inside mice in new study
Stanford researchers have successfully grown human brain tissue inside specially engineered mice, creating what they describe as one of the most advanced models yet for studying human brain development and disease.
informacion.es
A team of researchers from Stanford University in the United States has developed a hybrid model in which organoids of human cerebral cortex grow within genetically modified mice and account for about 92% of measured cortical tissue.
Scientists Created Mice With Half-Human Brains. The Hybrid Animals Could Revolutionize Our Understanding of Neurological Disorders
Our brains and their associated diseases are notoriously hard to study. So, researchers developed an animal model with a cortex—the brain’s outer layer—grown from human-derived cells
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