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HIV drugs found to significantly reduce Alzheimer's risk in new study

  • Researchers at the University of Virginia found that HIV drugs called NRTIs reduce Alzheimer's risk significantly in two large U.S. Health databases analyzed in 2025.
  • This study followed previous work linking inflammasomes to Alzheimer's and tested the drugs' anti-inflammatory effects that may explain the reduced risk.
  • The analysis of over 270,000 patients showed a 6% to 13% yearly decrease in Alzheimer's risk per year of NRTI use, while other HIV medications lacked similar effects.
  • Jayakrishna Ambati, MD, called the reduction "significant and substantial" and noted that a safer inflammasome-blocking drug, K9, now in trials, will be tested for Alzheimer's.
  • Given growing Alzheimer's prevalence and increasing care costs, these results support clinical trials of NRTIs and related drugs as potential preventive treatments.
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The Suncoast News & Scoop broke the news in on Thursday, May 8, 2025.
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