HIV drugs found to significantly reduce Alzheimer's risk in new study
- Researchers at the University of Virginia found that HIV drugs called NRTIs reduce Alzheimer's risk significantly in two large U.S. Health databases analyzed in 2025.
- This study followed previous work linking inflammasomes to Alzheimer's and tested the drugs' anti-inflammatory effects that may explain the reduced risk.
- The analysis of over 270,000 patients showed a 6% to 13% yearly decrease in Alzheimer's risk per year of NRTI use, while other HIV medications lacked similar effects.
- Jayakrishna Ambati, MD, called the reduction "significant and substantial" and noted that a safer inflammasome-blocking drug, K9, now in trials, will be tested for Alzheimer's.
- Given growing Alzheimer's prevalence and increasing care costs, these results support clinical trials of NRTIs and related drugs as potential preventive treatments.
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HIV drugs found to significantly reduce Alzheimer's risk in new study
UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer's disease after discovering that patients taking the drugs are substantially less likely to develop the memory-robbing condition.
HIV drugs offer 'substantial' Alzheimer's protection, new research suggests
UVA Health scientists are calling for clinical trials testing the potential of HIV drugs called NRTIs to prevent Alzheimer's disease after discovering that patients taking the drugs are substantially less likely to develop the condition. The researchers have published their findings in Alzheimer's & Dementia.
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