US EditionMore early stage colon cancers found in people aged 45-49 due to more screenings, research shows
UNITED STATES, AUG 5 – Screening rates for colorectal cancer in adults 45 to 49 rose from 20.8% in 2019 to 33.7% in 2023, linked to a 50% increase in early-stage diagnoses, researchers say.
- A new study in BMC Cancer introduces a nomogram-based model linking lifestyle factors to colorectal cancer incidence using NHIS data from 2009 to 2012.
- The research team applied LASSO regression to select predictors such as BMI, smoking status, and abdominal obesity, then used a Cox proportional hazards model.
- Performance metrics revealed that concordance indices of 0.60–0.70 demonstrated moderate predictive accuracy, with calibration via 10-fold cross-validation aligning predicted and observed CRC rates.
- The model empowers individuals and clinicians to make evidence-based CRC prevention decisions, as high-risk participants showed elevated cumulative incidence, underscoring its public health utility.
- Future work may integrate genetic and microbiome data for refined risk stratification, and authors call for external validation in diverse populations.
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More Adults Aged 45–49 Being Screened, Diagnosed With Colon Cancer: Studies
More younger adults are being screened for and diagnosed with colon cancer, according to studies published on Aug. 4. Colon cancer cases among adults aged 45 to 49 increased 12 percent annually from 2019 through 2022, up from an increase of 1.1 percent annually from 2004 through 2019, researchers reported in one of the studies. Smaller increases for other age ranges—1.6 percent annually for adults aged 20 to 39 since 2004, 2 percent annually for…
More Colorectal Cancers Detected in Younger Adults After Guideline Change
(MedPage Today) -- The proportion of younger adults undergoing colorectal cancer (CRC) screening has increased in the years after recommendations were first revised to include average-risk individuals ages 45 to 49, and this led to earlier detection...
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