Heart Assembloids Offer New Human Model for Valve Disease
The chip-sized platform uses patient-derived stem cells and mechanical cues to model valve formation and several disorders, researchers said.
3 Articles
3 Articles
New heart assembloid model mimics complex valve disorders
A multi-disciplinary, multi-institution group of researchers focused their expertise in genetics, mechanics, chemistry and biology on a chip the size of a postage stamp in order to model a particular class of heart conditions.
Heart Assembloids Offer New Human Model for Valve Disease
Heart valve disease remains difficult to model. Human valves take weeks to develop, are shaped by complex mechanical forces, and differ substantially from the valves of commonly used animal models. This has left researchers with an experimental gap: the biology most relevant to patients often cannot be captured fully in either a dish or an animal. A new Cell Stem Cell study from researchers at the University of Pittsburgh and collaborating insti…
Heart assembloids give researchers a new way to study heart valve disorders
A multidisciplinary, multi-institution group of researchers focused their expertise in genetics, mechanics, chemistry and biology on a chip the size of a postage stamp to model a particular class of heart conditions.
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