Heart Assembloids Offer New Human Model for Valve Disease
The chip-sized platform uses patient-derived stem cells and mechanical cues to model valve formation and several disorders, researchers said.
- On Tuesday, University of Pittsburgh researchers published a study in Cell Stem Cell describing a new "assembloid" platform that generates human-like heart valve structures for disease modeling.
- Heart valve disease affects about 28 million people, yet research remains challenging because human valves differ significantly from animal models and require complex mechanical forces to develop.
- Associate professor Guang Li, PhD, of the University of Pittsburgh School of Medicine's Department of Cell Biology, led the team in engineering a postage-stamp-sized chip using stem cells, flowing medium, and magnetized beads to simulate heart forces.
- The platform successfully modeled mitral valve prolapse , a genetic disorder affecting 7 to 8 million individuals, allowing researchers to identify disease pathways and test potential corrections.
- Researchers now plan to generate two-chamber "assembloids" with internal valves to improve the system's utility for studying congenital defects, progressive valve degeneration, and therapy responses.
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11 Articles
Researchers in Australia have created human heart valve tissue from stem cells, providing a new platform for advancing treatments for childhood heart disease.
New heart assembloid model mimics complex valve disorders
A multi-disciplinary, multi-institution group of researchers focused their expertise in genetics, mechanics, chemistry and biology on a chip the size of a postage stamp in order to model a particular class of heart conditions.
Heart Assembloids Offer New Human Model for Valve Disease
Heart valve disease remains difficult to model. Human valves take weeks to develop, are shaped by complex mechanical forces, and differ substantially from the valves of commonly used animal models. This has left researchers with an experimental gap: the biology most relevant to patients often cannot be captured fully in either a dish or an animal. A new Cell Stem Cell study from researchers at the University of Pittsburgh and collaborating insti…
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op-online.deHeart Valves From Stem Cells: Why Australia's Research Could Save Children From Follow-up Operations
Australian researchers are breeding heart valve tissue from stem cells for the first time. It could grow with children and spare subsequent operations.
Researchers in Australia have developed heart valve tissues similar to those in humans using stem cell technology.
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