Gut Immune Responses Found to Trigger Brain Inflammation in MS

Gut immune responses found to trigger brain inflammation in MS

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS).

Gut 'primes' pathogenic T cells responsible for neuroinflammation in multiple sclerosis, study finds

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). What makes the body turn against itself? Failure of the immune system to distinguish "self" from "non-self" entities leads to excessive autoimmune responses against self-proteins like myelin, which forms a protective covering on the neurons.

How Intestinal Cells Trigger Multiple Sclerosis

Researchers have discovered that gut lining cells trigger the neuroinflammation seen in Multiple Sclerosis. By mistakenly "presenting" antigens, these cells create pathogenic Th17 cells that migrate to the brain and spinal cord.

Gut-Immune Link Identified in Multiple Sclerosis-Related Neuroinflammation

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). New research led by Shohei Suzuki, MD, PhD, assistant professor, division of gastroenterology and hepatology, and Tomohisa Sujino, PhD, associate professor, School of Medicine, at Keio University, Japan, has now indicated how the gut can initiate neuroinflammation in …