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GLP-1RAs linked to lower risk of mortality and cardiovascular events in psoriasis patients

Psoriasis patients using GLP-1 receptor agonists had 78% lower mortality and 44% fewer major cardiovascular events; risks of alcohol and substance abuse also decreased, study finds.

  • Researchers revealed in Paris on September 17, 2025, that GLP-1 receptor agonists are associated with reduced mortality and lower cardiovascular risk among psoriasis patients in the United States.
  • The study examined data from more than 6,000 individuals with psoriasis who also had diabetes or obesity and received continuous treatment for two years with either GLP-1 receptor agonists or alternative anti-diabetic medications, with groups balanced for age, gender, and existing health conditions.
  • GLP-1RA users showed a 78% lower risk of death, a 44% reduced risk of major cardiovascular events, plus a 65% drop in alcohol abuse and nearly 50% in substance abuse compared to controls.
  • Lead author Professor Ralf Ludwig explained that GLP-1 receptor agonists could provide advantages that extend past their typical roles in managing weight and blood sugar, including potential improvements in cardiovascular health and mental well-being among individuals with psoriasis.
  • These findings emphasize that psoriasis management should address wider health risks, as GLP-1RAs offer a safe, dual benefit potentially making them preferred therapy for psoriasis patients with metabolic needs.
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Medical Xpress broke the news in on Wednesday, September 17, 2025.
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