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Gilead to buy Germany's Tubulis for up to $5 billion to boost cancer pipeline

  • On Tuesday, Gilead Sciences announced it will acquire German biotech Tubulis in a deal valued at up to $5 billion, including a $3.15 billion upfront payment and $1.85 billion in milestone-based payments.
  • Gilead Chief Executive Daniel O'Day said the acquisition is "a significant milestone" as the company expands its oncology pipeline ahead of HIV patent expirations in coming years.
  • Tubulis specializes in stable antibody-drug conjugates, with lead assets TUB-040 and TUB-030 targeting platinum-resistant ovarian cancer and other solid tumors using specialized protein-linking technology.
  • This acquisition follows Gilead's recent $7.8 billion deal for Arcellx and up to $2.18 billion offer for Ouro Therapeutics, marking its third major acquisition this year.
  • While antibody-drug conjugates show promise, the category faces clinical risks; ADC Therapeutics' trial failures underscore challenges Gilead navigated through its $21 billion Immunomedics acquisition and Trodelvy experience.
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The Munich-based cancer research company Tubulis was considered one of the great German sources of hope in the biotech industry. The start-up is now taken over by the US pharmaceutical giant Gilead.

·Düsseldorf, Germany
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Business Wire broke the news in Crystal River, United States on Monday, April 6, 2026.
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