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Friends study points to ctDNA’s potential to serve as an intermediate endpoint in NSCLC ctMoniTR project aims to improve efficiency in development of intermediate endpoints

New research led by Friends of Cancer Research demonstrates that decreases in circulating tumor DNA after initiation of treatment are associated with improved overall survival in patients with advanced non-small cell lung cancer treated with immunotherapy or chemotherapy. The result is an early but promising signal that ctDNA—as a measurement of minimal residual disease—may be an effective intermediate endpoint for accelerated approval in NSCLC.…
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The Cancer Letter broke the news in on Friday, October 24, 2025.
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