Fractionated Radiosurgery Reduces Cancer Recurrence After Surgery for Large Brain Metastases

Splitting Brain Radiosurgery into Three to Five Sessions After Tumor Removal Lowered Recurrence in 242-Patient Trial

A 242-patient phase 3 trial found that split-dose radiosurgery after brain tumor surgery reduced recurrence. The results come from a conference talk.

Fractionated radiosurgery extends survival for brain metastasis patients

Delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced the risk of cancer returning at the surgical site compared with delivering the radiation in a single session, according to the results of the Alliance for Clinical Trials in Oncology A071801 presented today at the plenary session of the American Society for Radiation Oncology in Boston.

Fractionated radiosurgery reduces cancer recurrence after surgery for large brain metastases

Delivering focused radiation therapy over three to five sessions after surgery for a large brain metastasis reduced the risk of cancer returning at the surgical site compared with delivering the radiation in a single session, according to the first randomized Phase III clinical trial directly comparing the approaches.

Multi-fraction radiation significantly improves local control for large brain metastases

Stereotactic radiation delivered over three to five sessions after surgery significantly improved local control for patients with large, resected brain metastases compared with single fraction treatment.Results from the first randomized phase 3 trial comparing differing radiation schedules, presented at American Society for Radiation Oncology Annual Meeting, also showed an association with a

Will Fractionated Radiation Become Standard of Care for Brain Metastases?

Investigators expect rapid adoption of fractionated stereotactic radiosurgery for resected brain metastases following new results of a randomized trial.

Fractionated SRS Should Be Standard of Care After Brain Metastasis Surgery

Ayal Aizer, MD, MHS, says Alliance A071801 supports fractionated SRS as standard after resection, with comparable radiation necrosis rates.