World Health Organization collaborating centers have recommended a complete replacement of all three viral components in Northern Hemisphere influenza vaccines for the 2024–2025 season, reflecting the near-total displacement of previously circulating strains by antigenically distinct variants. The updated trivalent formulation targets two influenza A subtypes — A/H1N1 and A/H3N2 — and one influenza B/Victoria lineage virus, based on year-round s…
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