US EditionHuman Organoids: Model Systems for Human Biology and Medicine
- A team of experts at Cincinnati Children's has successfully created human lung tissue capable of producing its own blood vessels.
- Prior to this study, lung organoids with organotypic vasculature had not been developed, indicating a significant advancement in organoid medicine.
- The study showed that the rare disease ACDMPV occurs when cell signaling 'crosstalk' is disrupted.
- Cincinnati Children's has filed patent applications for the methods developed to produce organoids with blood vessel formation capabilities.
42 Articles
42 Articles
Lab-grown 'tiny hearts' bring hope for children and adults with genetic heart disease
Scientists from QIMR Berghofer's Cardiac Bioengineering Lab have developed lab-grown, three-dimensional heart tissues known as cardiac organoids that mimic the structure and function of real adult human heart muscle.
Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids — which are stem cell-derived 3D culture systems — it is now possible to re-create the architecture and physiology of human organs in remarkable detail. Human organoids provide unique opportunities for the study…
Optimizing Tissue Clearing Protocols for Whole-Organoid Imaging of Human Cortical and Retinal iPSC-Derived Models
Background: Three-dimensional brain organoids derived from human induced pluripotent stem cells provide valuable in vitro systems for studying human brain development and neurological disorders. However, their dense and heterogeneous structure presents significant challenges f...
Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases
Organoids, exhibiting the capability to undergo differentiation in specific in vitro growth environments, have garnered significant attention in recen…
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