US EditionFirst antibiotic in 50 years to tackle superbug in final testing
- Roche, a Swiss pharmaceutical company, announced it will begin late-stage human trials of zosurabalpin, a novel antibiotic targeting drug-resistant Acinetobacter baumannii, in 2025.
- This development follows decades without new antibiotic classes active against Gram-negative bacteria like Acinetobacter, which causes severe infections and kills 40-60% of affected patients globally.
- The phase 3 trial will enroll about 400 hospitalized patients with carbapenem-resistant Acinetobacter baumannii infections and compare zosurabalpin against standard treatments, as previous phases confirmed safety and tolerability.
- Michael Lobritz, Roche's global head of infectious diseases, stated that their aim is to drive innovative solutions to address the critical public health issue of antimicrobial resistance, highlighting the drug’s role in advancing future antibiotic discoveries.
- If authorized, zosurabalpin would represent the first novel antibiotic in approximately five decades to target these resistant superbugs, aligning with critical priorities set by the World Health Organization and contributing to the global effort against escalating antimicrobial resistance.
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This new antibiotic may finally put a stop to some of the world’s most drug-resistant pathogens
“Gram-negative bacteria” pose a huge threat to public health. With deathly adaptability, these types of bacteria are able to develop resistance to many antibiotics and survive in a wide range of conditions. In particular, Acinetobacter baumannii, also known as CRAB, is one of clinical medicine’s most antibiotic resistant pathogens, killing hundreds in the U.S. every year with estimated mortality rates ranging from 26.0% to 55.7%. But a new antib…
They would use it to target a pathogen responsible for numerous hospital infections and millions of deaths each year.
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