Fibromyalgia has 'clear biological basis' - genetic study
Researchers found DNA variants in 26 genome regions and a strong HTT gene link, offering new clues to fibromyalgia risk and treatment.
- A landmark study published in Nature Medicine identified DNA variants in 26 regions of the genome linked to fibromyalgia risk, providing the strongest evidence that fibromyalgia is a neurological disorder rather than an autoimmune disease.
- For decades, patients have been "dismissed" or told their pain was psychological, but the condition has lacked clear biological explanation until now. This study confirms fibromyalgia has a clear biological basis in nervous system dysfunction.
- The global research team analyzed genetic data from more than 2.5 million adults, including 55,000 patients diagnosed with fibromyalgia, across 11 health studies spanning the US, UK, Finland, Denmark, Iceland and Estonia.
- Findings link fibromyalgia to the HTT gene, already the focus of drug trials for Huntington's disease, raising the possibility that existing pharmaceutical research could "eventually benefit people with fibromyalgia."
- The Chronic Pain Genomics Consortium, led by Dr. Michael Wainberg and Dr. Nasa Sinnott-Armstrong, plans to investigate other chronic pain syndromes starting with pelvic pain, positioning fibromyalgia as the beginning of broader chronic pain research.
13 Articles
13 Articles
Genetic study identifies 26 regions on genome affecting ones risk of fibromyalgia - The Tribune
A study has identified genetic risk factors of developing fibromyalgia, a chronic pain condition characterised by widespread pain and tenderness, fatigue, and problems with sleep, memory and mood.
A study identifies alterations in DNA linked to this syndrome and argues that the nervous system plays a key role in the development of the condition.
Genetic Study of Fibromyalgia Points to Neurological Basis
An international team of researchers has identified multiple new genetic risk factors associated with fibromyalgia, a syndrome characterized by widespread pain and tenderness, fatigue, and problems with sleep, memory and mood. The team analyzed genetic data from more than 2.5 million adults, of which 55,000 were fibromyalgia patients. They identified DNA sequence variants in 26 regions of the genome that affect the risk of developing fibromyalgi…
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