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Fabrication of Gastroretentive and Extended-Release Famotidine Floating Tablets via Fused Deposition Modeling
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Fabrication of Gastroretentive and Extended-Release Famotidine Floating Tablets via Fused Deposition Modeling
Abstract Famotidine suffers from low oral bioavailability due to poor aqueous solubility, short half-life, and limited gastric retention. This study aimed to develop gastro-retentive floating tablets of famotidine using hot-melt extrusion (HME) and fused deposition modeling (FDM) 3D printing approach to enhance its solubility, prolong gastric residence, and achieve extended drug release. Famotidine was incorporated into various polymeric carrier…
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