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Enhancing the Potency of In Vivo Lentiviral Vector Mediated Gene Therapy to Hepatocytes
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Enhancing the Potency of In Vivo Lentiviral Vector Mediated Gene Therapy to Hepatocytes
The authors showed that the a posteriori enhancement increased transgene output without expansion of hepatocytes bearing lentiviral vector genomic integrations near cancer genes, in mouse models of hemophilia, an inherited coagulation disorder. [Nature Communications] Full Article
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