Engineered protein silences harmful T cells in autoimmune disease

Engineered protein silences harmful T cells in autoimmune disease

An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.

Global DNA methylation changes in treated and untreated MS patients measured over time

Multiple sclerosis (MS) is an autoimmune, neurological disease. We investigated genome-wide DNA methylation profiles of CD4+ and CD8+ T cells from MS …

Disarished the rebel immune cells, responsible for many diseases - Global Happenings

A Protein engineered in the laboratory he managed to disarm the Rebel immune cells,That attack the body to which they belong unleashing the so -called autoimmune diseases.. the result, obtained on micecould open the way to future therapies against autoimmune diseases such as the type 1 diabetesand the Multiple sclerosis. Published in the Cell magazine, it is due to research Conducted by the New York University School of Medicine of Medicine, the…

JCI OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination

Stem-like T cells selectively contribute to autoimmunity, but the activities that promote their pathogenicity are incompletely understood. Here, we identify the transcription coregulator OCA-B as a driver of the pathogenic maturation of stem-like CD4+ T cells to promote autoimmune demyelination. Using 2 human multiple sclerosis (MS) datasets, we show that POU2AF1, the gene encoding OCA-B, is elevated in CD4+ T cells from patients with MS. We sho…