Synergy of two human endogenous retroviruses in multiple myeloma

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses - Retrovirology

Integration of retroviral DNA into a germ cell may lead to a provirus that is transmitted vertically to that host's offspring as an endogenous retrovirus (ERV). In humans, ERVs (HERVs) comprise about 8% of the genome, the vast majority of which are truncated and/or highly mutated and no longer encode functional genes. The most recently active retroviruses that integrated into the human germ line are members of the Betaretrovirus-like HERV-K (HML…

Synergy of two human endogenous retroviruses in multiple myeloma

Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM…

Ocular involvement in multiple myeloma

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According to the American Cancer Society, over 36,000 new cases of multiple myeloma are expected this year, and approximately 12,000 will die from the disease.

Effective Bridging Therapy Correlates With Improved PFS After Cilta-Cel in Multiple Myeloma

Improved PFS was associated with at least a 25% reduction in tumor burden before treatment with cilta-cel in patients with relapsed/refractory multiple myeloma.