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Diketopiperazine Alkaloids Discovered via Heterologous Expression
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Diketopiperazine Alkaloids Discovered via Heterologous Expression
In a ground-breaking study that promises to reshape the future of antibiotic discovery and biosynthetic chemistry, researchers have unveiled a novel class of diketopiperazine alkaloids derived from the enigmatic endophytic bacterium Kitasatospora sp. CPCC204717. This achievement was made possible through sophisticated heterologous expression of a previously cryptic biosynthetic gene cluster containing a tRNA-dependent cyclodipeptide synthase (CD…
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