Diabetes patient produces own insulin after gene-edited cell transplant – without anti-rejection drugs

Diabetes patient produces own insulin after gene-edited cell transplant – without anti-rejection drugs

In December 2024, a 42-year-old Swedish man with type 1 diabetes received 17 injections of donated islet cells. They had been genetically modified via CRISPR to avoid the need for immunosuppressive medicine.Read Entire Article

Diabetic Man With Gene-Edited Cells Produces His Own Insulin—No Transplant Drugs Required

A proof-of-concept study finds that donated insulin-producing cells can be genetically modified to avoid provoking the recipient's immune system.

Type 1 diabetes treatment without anti-rejection drugs

Using "CRISPR-Cas12b-edited donor islet cells targeting depletion of HLA class I and II to protect against adaptive T-cell rejection and overexpression of CD47 to inhibit innate immune-cell killing", researchers have successfully cured type 1 diabetes in mice (free account required). Oh, and they've had promising results in a human, too (free account required, too). Human-readable summaries at Techspot and Crispr Medicine News. Unlike treatments…