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Depression, Anxiety Increase Heart Disease Risk Through Stress

A study of over 85,500 participants found that having both depression and anxiety raises heart attack and stroke risk by about 32%, linked to brain stress and inflammation.

  • Researchers at Mass General Brigham found that depression and anxiety are linked to higher risk of heart attack, heart disease and stroke, reported by HealthDay on Dec. 17.
  • Researchers linked biological markers including increased amygdala activity and higher CRP levels to depression and anxiety, Dr. Shady Abohashem reported in Circulation: Cardiovascular Imaging.
  • Using data from more than 85,500 participants, researchers followed them for a little over three years during which over 3,000 cardiovascular events occurred, and the associations persisted after adjusting for risk factors.
  • For clinicians, the study is a reminder that mental health must be part of cardiovascular risk assessment, while researchers note the observational design cannot prove cause and effect.
  • The study suggests that combined mood disorders increase risk, with people with both depression and anxiety facing roughly 32% higher risk, forming a biological chain linking emotional stress to heart risk.
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Depression, Anxiety Increase Heart Disease Risk Through Stress, Experts Say

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KULR-TV broke the news in Billings, United States on Friday, December 19, 2025.
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