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Deep Brain Stimulation Boosts Myelination and Shifts Brain Networks Linked to Depression

Researchers found the therapy increased myelination and altered brain-wide connectivity, offering a biological explanation for sustained relief in treatment-resistant depression.

Summary by Medical Xpress
Researchers from the Icahn School of Medicine at Mount Sinai have uncovered the first direct evidence that deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks, revealing a previously unrecognized mechanism that may explain how the therapy helps patients recover from severe depression. The study, published June 1 in Nature Neuroscience, provides critical insight into the biological basis of DBS, an emerging therapy for treatment-resistant depression and other neuropsychiatric disorders.

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Newswise broke the news in Charlottesville, United States on Monday, June 1, 2026.
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