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Psychedelic Nasal Spray Shows Promise Against Depression

  • Beckley Psytech and atai Life Sciences announced positive Phase 2b trial results for BPL-003, an intranasal psychedelic for treatment-resistant depression.
  • The eight-week study tested 8mg and 12mg doses of mebufotenin against a 0.3mg control in 193 patients, enabling plans to merge and start Phase 3 trials.
  • Both doses produced significant MADRS score reductions of around 12 points, with most patients discharged within 90 minutes and no serious side effects reported.
  • Beckley CEO Cosmo Feilding Mellen said the findings reinforce BPL-003's potential as a viable treatment, while shares rose about 27% on the news.
  • These results support advancing the 8mg dose into pivotal trials and suggest BPL-003 may offer a longer treatment window than competitors like Spravato.
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Mebufotenin benzoate also requires a much shorter period of clinical supervision in trial

·London, United Kingdom
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stocktitan.net broke the news in on Tuesday, July 1, 2025.
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