Psychedelic Nasal Spray Shows Promise Against Depression
- Beckley Psytech and atai Life Sciences announced positive Phase 2b trial results for BPL-003, an intranasal psychedelic for treatment-resistant depression.
- The eight-week study tested 8mg and 12mg doses of mebufotenin against a 0.3mg control in 193 patients, enabling plans to merge and start Phase 3 trials.
- Both doses produced significant MADRS score reductions of around 12 points, with most patients discharged within 90 minutes and no serious side effects reported.
- Beckley CEO Cosmo Feilding Mellen said the findings reinforce BPL-003's potential as a viable treatment, while shares rose about 27% on the news.
- These results support advancing the 8mg dose into pivotal trials and suggest BPL-003 may offer a longer treatment window than competitors like Spravato.
17 Articles
17 Articles


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Mebufotenin benzoate also requires a much shorter period of clinical supervision in trial
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