Published 24 days ago • loading... • Updated 23 days ago

CStone Presents the Latest Preclinical Findings of CS2009 (PD-1/VEGF/CTLA-4 trispecific antibody) at 2025 AACR

On May 5, 2025, CStone Pharmaceuticals shared findings from early-stage studies of CS2009, a trispecific antibody targeting PD-1, VEGF, and CTLA-4, during the 2025 AACR Annual Meeting held in Suzhou, China.
CStone developed CS2009 to combine blockade of PD-1, VEGFA, and CTLA-4, clinically validated immunotherapy targets known for synergistic anti-tumor effects and extended survival benefits.
CS2009 enhances efficacy by targeting PD-1/CTLA-4 double-positive T cells and crosslinking VEGFA dimers, showing an up to 300-fold increase in checkpoint inhibitory activity in assays.
Preclinical evaluations showed that CS2009 activates T-cells in a dose-dependent manner, has pharmacokinetic characteristics similar to monoclonal antibodies, is very well tolerated, and exhibited no adverse effects at doses up to 100 mg/kg in cynomolgus monkeys.
The global phase I trial started in March 2025 in Australia and will expand to China and the US, supporting CS2009's potential as a next-generation immune-oncology backbone against solid tumors including NSCLC.

Insights by Ground AI

Does this summary seem wrong?

70 Articles

All

Left

Center

Right

InsideNoVA.com

Charleston Gazette-Mail

Watauga Democrat

TBNweekly

Local 3 News

The Herald-Dispatch

The Courier Express

The Laconia Daily Sun

Islander News

Brattleboro Reformer

The Daily News

Bennington Banner

Mt. Airy News

Suncoast News

Rutland Herald

Queens Chronicle

The Berkshire Eagle

Times Argus

Livingston County News

The Coal Valley News

Central Connecticut Communications

The Paintsville Herald

MyHorryNews.com

The Times-News

Hometown News Volusia

romesentinel.com

The Daily Press

Appalachian News-Express

Biltmore Beacon

The Elkin Tribune

The Ridgway Record

thebesttimes.com

The Miami Times

Fairfax County Times

Community News

Colchester Sun

Carroll News

Rappahannock News

Coastal Point

Westminster Cable Network

The Courier-Tribune

YourGV.com

Daytona Times

Lincoln Times News

Johnson City Press

Kingsport Times-News

waynecountynews.com

Morgan County Citizen

williamsondailynews.com

Independent-Messenger

mainstreetnews.com

winchesternewsgazette.com

thepilotnews.com

Smith Mountain Eagle

newsontheneck.com

The Daily News - Jacksonville, NC

newportvermontdailyexpress.com

News of Orange

thesussexsurrydispatch.com

thesentinel.com

kentuckytoday.com

keenesentinel.com

coastaltvnews.com

willistonobserver.com

decaturdailydemocrat.com

theritchiegazette.com

miltonindependent.com

theohiopressnetwork.com

dailytimesleader.com

+68 Reposted by 68 other sources

Center

CStone Presents the Latest Preclinical Findings of CS2009 (PD-1/VEGF/CTLA-4 trispecific antibody) at 2025 AACR

SUZHOU, China, May 5, 2025 /PRNewswire/ -- CStone Pharmaceuticals ("CStone", HKEX: 2616), an innovation-driven biopharmaceutical company focused on anti-cancer therapies, announced today that a poster presentation of preclinical data of CS2009 (PD-1/VEGF/CTLA-4 trispecific antibody), a key asset in CStone Pipeline…

23 days ago

Read Full Article

ajmc.com

Experts Share Top Takeaways From AACR Annual Meeting 2025

During interviews at the American Association for Cancer Research (AACR) Annual Meeting 2025, experts shared key insights from this year's conference.

24 days ago

Read Full Article

Think freely.Subscribe and get full access to Ground NewsSubscriptions start at $9.99/year