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CRISPR-Cas9 induced formation of Myc-containing ecDNA drives carcinogenesis in mouse liver and cancer phenotypes in human cell models
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CRISPR-Cas9 induced formation of Myc-containing ecDNA drives carcinogenesis in mouse liver and cancer phenotypes in human cell models
Over 40% of human cancers harbor extrachromosomal DNA (ecDNA), which correlates with therapy resistance and poor prognosis. Yet research is limited by a lack of robust de novo ecDNA models. We present a CRISPR-Cas9 based approach for generation of ecDNA in cell lines and mouse liver. In HEK293 ce...
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