US EditionUpdated COVID Vaccines Effective Against New Strains
- Researchers published a June 25, 2025 study in JAMA Network Open evaluating 2023-2024 COVID-19 vaccines in eight U.S. states during Omicron subvariant waves.
- The study arose from CDC's VISION Network amid ongoing viral evolution and waning immunity, despite FDA requirements for placebo-controlled vaccine trials.
- Researchers analyzed over 345,000 emergency or urgent care visits and 111,000 hospitalizations, finding vaccines reduced severe outcomes especially in adults 65 and older.
- Updated vaccines lowered emergency visits by 24%, hospitalizations by 29%, and critical illness by 48% within 7 to 299 days, with maximum protection in the first two months.
- The results emphasize the continued necessity of receiving the latest COVID-19 vaccines to protect against severe illness, especially among older adults and vulnerable populations, in alignment with CDC guidance on staying current with vaccinations and booster shots.
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InsideNoVA.com
Updated COVID Vaccines Effective Against New Strains
Key Takeaways
Updated COVID-19 vaccines found effective against severe illness
A new multi-state study led by the Centers for Disease Control and Prevention's (CDC) VISION Network – including Regenstrief Institute – has provided the most comprehensive assessment to date of the effectiveness of 2023-2024 COVID-19 vaccines among adults in the U.S. during the XBB and JN.1 Omicron subvariant waves.
Updated COVID vaccine reduces risk of severe illness and death, especially for high-risk adults
A new multi-state study led by the Centers for Disease Control and Prevention's (CDC) VISION Network—including Regenstrief Institute—has provided the most comprehensive assessment to date of the effectiveness of 2023–2024 COVID-19 vaccines among adults in the U.S. during the XBB and JN.1 omicron subvariant waves.
Do booster vaccinations with updated corona vaccines have an effect? According to US data, yes. In 2023 and 2024, they were able to reduce the risk of serious disease progression by almost half.
COVID-19 vaccines available in 2023-2024 were still offering extra pro
People who received the new COVID-19 vaccines available in 2023-2024 - targeting the XBB.1.5 Omicron variant - saw increased protection from hospitalisation and critical illness above general immunity from previous vaccines and infections, according to international research. The team used data from almost 350,000 emergency department presentations and over 100,000 hospitalisations in the US to find COVID-19 patients and estimate the effectivene…
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