US EditionComparative study of Hot-Melt Extrusion, spray drying, and KinetiSol® processing to formulate a poorly water-soluble and thermolabile drug - Pharma Excipients
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Comparative study of Hot-Melt Extrusion, spray drying, and KinetiSol® processing to formulate a poorly water-soluble and thermolabile drug - Pharma Excipients
Abstract Fenbendazole (FBZ), a benzimidazole-carbamate anthelmintic, shows promising chemotherapeutic properties. However, it is a poorly water-soluble molecule, leading to low and variable oral bioavailability. This study investigated hot-melt extrusion (HME), spray drying, and KinetiSol processing (KSD) using Soluplus (SOL) to enhance FBZ’s solubility. Formulating FBZ as an amorphous solid dispersion (ASD) by HME at a barrel temperature of 120…
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