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Doxycycline Could Reduce Schizophrenia Risk

  • Analysing Finnish health records, researchers at the University of Edinburgh reported on Wednesday 5 November in the American Journal of Psychiatry that adolescents prescribed doxycycline were significantly less likely to develop schizophrenia.
  • Because doxycycline can cross the blood‑brain barrier and reduce inflammation, researchers from the University of Edinburgh used an emulated target trial approach with Finnish data to investigate its brain-modulating effects linked to schizophrenia biology.
  • The team analysed data from more than 56,000 adolescents, finding doxycycline users had a 30–35% lower schizophrenia risk and a 2.5% absolute risk reduction at 15 years.
  • Experts say the findings highlight the potential to repurpose doxycycline as a preventive intervention for severe mental illness, but randomized controlled trials are essential before its use.
  • Given marked group differences, researchers warn that marked confounding limits causal inference, and the lack of consistent dose-response and trial costs mean replication, biological work, and costly long-term randomized controlled trials are needed.
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Medical Xpress broke the news in on Wednesday, November 5, 2025.
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