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Common Ancestry Limits Protein Sequence Exploration, Computational Study Shows
For all the excitement surrounding AlphaFold and the surge of AI‑driven protein design tools, one fact often goes unexamined: nearly every model is trained on databases of known proteins. These databases feel vast, but compared to the astronomical number of sequences that could, in principle, form a functional protein, they represent only a sliver of what’s possible. That raises a fundamental question for the field: how representative is the pro…
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1 Articles
Common Ancestry Limits Protein Sequence Exploration, Computational Study Shows
For all the excitement surrounding AlphaFold and the surge of AI‑driven protein design tools, one fact often goes unexamined: nearly every model is trained on databases of known proteins. These databases feel vast, but compared to the astronomical number of sequences that could, in principle, form a functional protein, they represent only a sliver of what’s possible. That raises a fundamental question for the field: how representative is the pro…
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