Combination therapy shows promise in maintaining lower suicidal thoughts over time

New research finds low-dose buprenorphine may help sustain ketamine's benefits for suicidal ideation

New research published in the American Journal of Psychiatry finds that low-dose buprenorphine, given after a single ketamine infusion, significantly sustained reductions in suicidal ideation in adults with major depressive disorder.

Combination therapy shows promise in maintaining lower suicidal thoughts over time

New research published online today in the American Journal of Psychiatry finds that low-dose buprenorphine, given after a single ketamine infusion, significantly sustained reductions in suicidal ideation in adults with major depressive disorder.

Buprenorphin and Ketamine Combo Provide Anti-Suicidal Effect

A sequential combination of a single ketamine infusion followed by four weeks of low-dose daily buprenorphine successfully extends the antisuicidal window of ketamine from one fleeting week to over a month.

New Study Suggests Low-Dose Buprenorphine Enhances Ketamine’s Lasting

In a groundbreaking study published in the American Journal of Psychiatry on May 19, 2026, researchers unveiled a novel pharmacological strategy for sustaining the rapid anti-suicidal effects of ketamine in adults suffering from major depressive disorder. This research pioneered the combination of a single intravenous ketamine infusion followed by a regimen of low-dose buprenorphine over four weeks, demonstrating a significant and prolonged redu…