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Coffee helps protect your body from aging and disease, study says
Researchers found that caffeic and chlorogenic acids, plus kahweol and cafestol, activated NR4A1 and reduced inflammation in lab models.
- Researchers at Texas A&M University College of Veterinary Medicine and Biomedical Sciences discovered that coffee compounds bind to the NR4A1 receptor, a protein linked to aging, stress response, and disease.
- Stephen Safe, distinguished professor and chair in VMBS, described NR4A1 as a "nutrient sensor" that responds to dietary compounds and helps regulate gene activity during stress and tissue damage.
- While caffeine is the major component, researchers found that polyphenols are "much more active," explaining why both regular and decaffeinated coffee show similar health benefits in population studies.
- Because NR4A1 manages inflammation and tissue repair, Safe's team is exploring synthetic compounds targeting the receptor more effectively than natural dietary options for treating cancer and disease.
- Despite these findings, Safe noted there is "still a lot of work to be done," as the study is mechanistic and does not yet prove direct cause-and-effect in humans.
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Drinking coffee linked to slower aging and better health
Coffee has long carried an unusual reputation in nutrition research. It is a daily habit, not a medicine, yet study after study has tied it to longer life and lower risk of diseases that often come with aging. Now a team at Texas A&M University says it may have found part of the biological machinery behind that pattern. In research published in Nutrients, scientists at the Texas A&M College of Veterinary Medicine and Biomedical Sciences traced s…
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Total News Sources7
Leaning Left1Leaning Right0Center3Last UpdatedBias Distribution75% Center
Bias Distribution
- 75% of the sources are Center
75% Center
L 25%
C 75%
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