Clogged Brain Drains May Signal Early Alzheimer's Risk

Alzheimer's disease risk may be linked to 'clogged drains' symptom

Scientists believe they may have identified a potential early warning sign of Alzheimer's disease visible on routine MRI scans.

Clogged brain drains may signal early Alzheimer's risk

"Drains" in the brain, responsible for clearing toxic waste in the organ, tend to get clogged up in people who show signs of developing Alzheimer's disease, a study by researchers from Nanyang Technological University, Singapore (NTU Singapore) has discovered.

Alzheimer’s disease risk may be linked to ‘clogged drains’ symptom

A condition causing ‘clogged drains’ in the brain could be an early warning sign of dementia, according to new research. Scientists believe they can now identify these blockages through standard MRI scans, potentially enhancing current methods for early Alzheimer’s detection. The study, carried out by Nanyang Technological University in Singapore, involved nearly 1,000 participants from a variety of ethnic backgrounds. Participants underwent com…

Clearing Amyloid-β Does Not Improve Glymphatic Drainage in Alzheimer's Patients

The well understood pathways by which cerebrospinal fluid drains from the brain are the glymphatic system and cribriform plate. These paths become less functional with age, for different reasons, and the consequently reduced drainage of cerebrospinal fluid allows metabolic waste to build up in the brain. This includes the misfolded and normally folded but excess amyloid-β that is associated with the development of Alzheimer's disease. Researcher…