Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Certain chemotherapy drugs can age children’s healthy cells, with some children showing levels of genetic damage comparable to those found in adult tissues.

Platinum chemotherapy may cause decades' worth of DNA changes in children's healthy cells

The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate these effects.

Platinum-based chemotherapy in childhood causes mutations that age the liver

Platinum chemotherapy aged the liver cells of treated children, making them look more like adult liver cells and possibly raising the long-term risk of new tumors