Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Study reveals hidden DNA damage from childhood chemotherapy

The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate these impacts.

Childhood Chemotherapy Leaves Lasting DNA Damage in Healthy Tissues

Certain chemotherapy drugs can age children’s healthy cells, with some children showing levels of genetic damage comparable to those found in adult tissues.

Platinum chemotherapy may cause decades' worth of DNA changes in children's healthy cells

The amount of DNA damage caused by certain chemotherapies used to effectively treat childhood cancer has been revealed, along with a hidden impact on the liver, paving the way for future research into new ways to mitigate these effects.

Platinum-based chemotherapy in childhood causes mutations that age the liver

Platinum-based chemotherapy medications cause mutations in DNA of healthy cells, potentially raising the risk of new cancers later in life.

Study Links Childhood Chemo to Later-in-Life Health Issues

Chemotherapy, which saves the lives of many children with cancer, causes previously unknown DNA alterations in the liver and leaves genetic footprints in other healthy cells as well. These findings could potentially explain the higher risk of health problems later in life.