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Como v Manchester United: Confirmed Line-Ups as Under-Pressure Carrick Seeks Champions League Respite
De Ligt starts after 325 days out as United cope with nine first-team absences and severe weather in northern Italy.
On Wednesday, Manchester United faces Como in the Champions League, with manager Michael Carrick naming defender De Ligt in the starting XI despite missing 325 days of competitive action.
Nine first-team players are unavailable due to injuries and illness, as Marcus Rashford and Lisandro Martinez both missed Tuesday training before the squad flew to Milan.
United enters the contest following a 1-1 draw with Leeds United, extending a six-game winless run, while Como midfielder Nico Paz contributed 12 goals and six assists in Serie A last season.
Alan Shearer recently criticized Manchester United's recruitment strategy, arguing the squad lacks necessary depth, despite Carrick reporting board support at his press conference.
Severe weather warnings remain in place for the Lombardy region, where heavy rainfall has battered the Giuseppe Sinigaglia stadium; despite the persistent downpour, the match will proceed at 5.45pm BST.
Matthijs de Ligt finally makes his return to Manchester United after nearly a year of injury woes. The Dutchman has a starting place in the Champions League match against Como.