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Cell nucleus shape plays a key role in cancer therapy outcomes
Researchers found that cancer cells with more deformable nuclei respond better to PARP inhibitors; stiffening nuclei with paclitaxel may reduce drug effectiveness, explaining adverse drug interactions.
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2 Articles
Cell nucleus shape may influence cancer treatment success
Cancer cells with a cell nucleus that is easily deformed are more sensitive to drugs that damage DNA. These are the findings of a new study by researchers at Linköping University in Sweden. The results may also explain why combining certain cancer drugs can produce the opposite of the intended effect. The study has been published in the journal Nature Communications.
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