Can Cancer Drugs Treat Osteoporosis and Midlife Weight Gain?
Researchers said the drug improved bone health and metabolism in post-menopausal mice, and 8-week treatment was well tolerated in animals.
- Researchers reported on Monday that the experimental cancer drug CADD522 strengthened bones and reduced body fat in mice mimicking menopause, according to a study published in npj Drug Discovery.
- Originally developed to block cancer growth, CADD522 is a small molecule inhibitor of the protein RUNX2, investigated to address limited therapeutic options for Osteoporosis, which affects one in three women over 50.
- Mice treated with CADD522 for eight weeks showed increased bone volume and better structural preservation, lead researcher Darrell Green from the University of East Anglia said, with the treatment also reducing fat deposits in bone marrow.
- Safety testing in mice, rats, and dogs found CADD522 was well tolerated and could be taken orally; the team also observed the drug reversed menopause-related abnormalities in brain fatty acids.
- While the study remains in early stages and has been tested only in animals, Darrell Green hopes the benefits will translate to humans to reduce fracture rates in future clinical trials.
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50 Articles
One Drug Could Target Two Big Menopause Problems
After menopause, many women notice changes that go far beyond the end of monthly periods. Falling estrogen levels can affect bones, muscles, fat storage and the way the body handles energy. One of the most serious long-term concerns is osteoporosis. The condition slowly weakens bones and makes fractures more likely, particularly in the hip, spine […]
Anticancer Candidate Strengthens Bones and Prevents Weight Gain in Postmenopausal Mice
A preclinical study in post-menopausal bone loss mouse models found that CADD522, a small-molecule drug targeting RUNX2, protected against osteoporosis, prevented fat gain, and reversed some of the metabolic changes linked to menopause. The post Anticancer Candidate Strengthens Bones and Prevents Weight Gain in Postmenopausal Mice appeared first on GEN - Genetic Engineering and Biotechnology News.
Cancer Drug Could Help Women Tackle Midlife Weight Gain, Study Finds
An experimental drug designed to fight cancer produced an unexpected result in a new study, leaving researchers looking far beyond its original purpose. Scientists at the University of East Anglia found that the compound not only strengthened bones in postmenopausal mice but also appeared to…
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