Canadian Researchers Develop Test They Say Can Help Diagnose Life-Threatening Sepsis
- A team of Canadian researchers developed a portable blood test called PowerBlade that can quickly predict sepsis risk in patients as of May 2025.
- The test arose from a collaboration using artificial intelligence to identify six gene markers called Sepset that indicate early abnormal immune response leading to sepsis.
- The PowerBlade device uses a small volume of blood—approximately one or two drops—to extract RNA and identify six key genes, producing results within three hours and achieving 92 percent accuracy when evaluated with 30 retrospective samples.
- Dr. Claudia dos Santos emphasized that sepsis kills thousands in Canada and nearly 50 million worldwide yearly, adding, "Treating sepsis quickly is crucial to survival."
- Researchers plan a CIHR-funded clinical trial to validate PowerBlade in real-time settings and assess how early detection changes patient outcomes.
21 Articles
21 Articles
A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
Sepsis is a life-threatening organ dysfunction due to a dysfunctional response to infection. Delays in diagnosis have substantial impact on survival. Herein, blood samples from 586 in-house patients with suspected sepsis are used in conjunction with machine learning and cross-validation to define a six-gene expression signature of immune cell reprogramming, termed Sepset, to predict clinical deterioration within the first 24 h (h) of clinical pre

Canadian researchers develop test they say can help diagnose life-threatening sepsis
Breaking News, Sports, Manitoba, Canada
Canadians devise rapid test to predict sepsis
TORONTO – A team of scientists from across Canada has developed an innovative molecular-based blood test and portable device to quickly predict the risk of sepsis over the first 24 hours of clinical presentation. The researchers have published a paper describing the test and its development in Nature Communications, showing it to be a major milestone in the way doctors will evaluate and treat sepsis. The study was the result of a collaboration b…
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