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Health Rounds: Fake X-Rays Created by AI Fool Radiologists and Even ...

A study of 17 radiologists and AI models across six countries found only 41% initially detected deepfake X-rays, with accuracy rising to 75% after being alerted to fakes.

  • On March 24, 2026, a study published in Radiology found that neither experienced radiologists nor advanced large language models can reliably distinguish authentic X-rays from AI-generated deepfake images.
  • Seventeen radiologists from 12 medical centers across six countries reviewed 264 X-ray images; only 41% spontaneously identified AI-generated scans despite clinical experience ranging from zero to 40 years.
  • Even when informed synthetic images were present, radiologist accuracy reached only 75%, while four large language models—GPT-4o, GPT-5, Gemini 2.5 Pro, and Llama 4 Maverick—ranged from 57% to 85% accuracy.
  • Dr. Mickael Tordjman of the Icahn School of Medicine at Mount Sinai warned that deepfake X-rays "creates a high-stakes vulnerability for fraudulent litigation if, for example, a fabricated fracture could be indistinguishable from a real one."
  • Researchers are calling for advanced digital safeguards including invisible watermarks and cryptographic signatures attached at image capture to verify authenticity and prevent malicious exploitation of generative AI tools.
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Health Rounds: Fake X-rays created by AI fool radiologists and even ...

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Nature broke the news in United Kingdom on Tuesday, March 24, 2026.
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