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Chelsea vs. Ajax Prediction, Lineups, Odds, TV and Bet Builder for Champions League Clash

Ajax Amsterdam seek their first Champions League points after two losses while Chelsea aim to maintain momentum despite key player absences, with Enzo Fernandez expected to play.

  • Chelsea FC welcome Ajax Amsterdam to Stamford Bridge for an 8pm BST kick-off on Wednesday, October 22, 2025, with live coverage on TNT Sports and streaming via Discovery+.
  • Ajax arrive having failed to score in the competition this season after 2-0 and 4-0 losses to Inter Milan and Marseille, while John Heitinga endures a difficult start as Ajax manager.
  • Missing Palmer and Joao Pedro, Chelsea will lean on Alejandro Garnacho, Marc Guiu and Pedro Neto to lead the attack.
  • Ajax announced a 23-man travelling squad on Tuesday but left key attackers Kasper Dolberg and Steven Berghuis behind, while Owen Wijndal, Ko Itakura and Don-Angelo Konadu remain available.
  • The 4-4 draw at Stamford Bridge in November 2019 highlights the fixture's goal-rich history, and teams with Weghorst and Klaassen are expected to produce goals.
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Evening Standard broke the news in London, United Kingdom on Tuesday, October 21, 2025.
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