Stem Cell-Derived Islet Therapies Shown to Reduce the Need for Injectable Insulin

Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes

Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from human embryonic stem cells found that insulin output was insufficient for clinical benefit. We are conducting a phase 1/2, open-label, multicenter trial aimed at optimizing cell engraftment (ClinicalTrials.gov identifier: NCT03163511 ). Here we report interim, 1-year outcomes in one study group that received 2–3-fold higher cell …

Stem Cell-Derived Islet Therapies Shown to Reduce the Need for Injectable Insulin

Breakthrough Studies Demonstrate Stem Cell-Based Technologies as a Potential Alternative Treatment for Type 1 Diabetes

Vertex Presents Positive Data for Zimislecel in Type 1 Diabetes at the American Diabetes Association 85th Scientific Sessions

BOSTON--(BUSINESS WIRE)--Jun 20, 2025-

Stem Cell-Derived Islets Still Producing Insulin at 1 Year

CHICAGO — Ten people with type 1 diabetes, who had recurrent severe hypoglycemia and hypoglycemic unawareness, have remained insulin-independent for over a year following allogeneic stem cell-derived islet-cell therapy with immunosuppression, according to new phase 1/2 data from the multicenter FORWARD study sponsored by Vertex Pharmaceuticals. The insulin-producing therapy VX-880, now named zimislecel, is delivered […] The post Stem Cell-Derive…

Vertex's diabetes cell therapy allows 10 patients to come off insulin

Vertex Pharmaceuticals’ cell therapy for type 1 diabetes allowed 10 of 12 patients (83%) to stop taking insulin a year after they were infused, according to results presented Friday. The data came from the Phase ...

Breakthrough: Vertex's Stem Cell Therapy Eliminates Insulin Need in 83% of Type 1 Diabetes Patients - NEJM Study

New clinical data reveals groundbreaking results for Vertex's zimislecel: 12/12 patients hit glucose targets, most achieve insulin independence. See full NEJM findings.