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Bone-Eating Cells Sabotage the Brain's Drainage System to Help Tumors
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Bone-Eating Cells Sabotage the Brain’s Drainage System to Help Tumors
When cancer spreads to the dura mater, the tough outermost membrane that envelops the brain and spinal cord, the prognosis is grim and the biology has remained stubbornly opaque. Dural metastasis, a devastating complication of advanced breast and lung cancers, has long been treated clinically as a cousin of brain metastasis, yet it behaves in […]
Bone-Eating Cells Sabotage the Brain's Drainage System to Help Tumors
A new Nature study shows that tumor-recruited osteoclasts secrete angiopoietin-2 to destroy meningeal lymphatic vessels in dural metastasis, and that targeting these bone-resorbing cells restores drainage and revives anti-tumor immunity.
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