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Alzheimer's Disease Blood Biomarkers Increase up to 95% Faster in Obese Individuals
Obesity accelerates Alzheimer's blood biomarker increases by up to 95%, suggesting faster disease progression, based on five-year data from 407 participants in the Alzheimer's Disease Neuroimaging Initiative.
- On Dec. 2, 2025, researchers presented at the Radiological Society of North America that blood-based biomarkers rose up to 95% faster in people with obesity than in non-obese individuals.
- Researchers analyzed five-year ADNI data from 407 participants, testing plasma pTau217, neurofilament light chain and GFAP with six leading commercial tests, validating BBMs against amyloid PET and using statistical models assessing BMI-time-BBM interactions.
- At baseline, body mass index correlated with lower blood biomarkers and reduced whole‑brain amyloid burden, but obesity led to a 24% faster plasma neurofilament light chain increase and 3.7% faster amyloid accumulation.
- Implications for clinical practice include obesity being a potential risk factor, with Dr. Raji noting `this is the first time we've shown the relationship between obesity and Alzheimer's disease as measured by blood biomarker tests.`
- Caution is advised because results remain preliminary until peer‑reviewed publication; Raji expects longitudinal blood biomarkers and brain imaging will monitor patients on anti‑amyloid drugs, while trials could test obesity/weight‑loss drugs.
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Blood test shows obesity speeds Alzheimer's development
Researchers have conducted the first study evaluating the impact of obesity on Alzheimer's disease blood biomarkers (BBMs). BBM values increased up to 95% faster in individuals with obesity than in non-obese individuals, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).
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Leaning Left3Leaning Right4Center7Last UpdatedBias Distribution50% Center
Bias Distribution
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50% Center
L 21%
C 50%
R 29%
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