MLB Best Bets for Sept. 22: Odds, Expert Picks for Pirates vs. Cardinals, Red Sox vs. Guardians and Mariners vs. Astros

Best bets for Brewers vs. Phillies, Mets vs. Rangers and more on Tuesday, Sept. 22

Find best bets for the biggest games in sports on Tuesday from the SportsLine Projection Model and top CBS Sports experts

MLB best bets for Sept. 22: Odds, expert picks for Pirates vs. Cardinals, Red Sox vs. Guardians and Mariners vs. Astros

Here's an outline of some MLB games worthy of wagering on for Tuesday night.

Astros vs. Mariners Prediction, Odds, Probable Pitchers, Prop Bets for Tuesday, Sept. 22

Houston Astros vs. Seattle Mariners betting odds, how to watch, probable pitchers, and MLB picks and props for Tuesday, September 22.

Astros vs Mariners Player-Prop Picks on Sep 22

The Houston Astros (77-79) travel to the Pacific Northwest to open a short two-game series against the Seattle Mariners (73-83). First pitch is scheduled for 9:40 PM ET on Tuesday, September 22 at T-Mobile Park. Houston enters as the likely road favorite, while the underdog Mariners look to protect home turf. Isolating individual performances provides … Continued