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Artificially-Sweetened and Sugary Drinks Linked to Higher Risk of Non-Alcoholic Fatty Liver Disease

A study of 123,788 UK participants found daily intake of sugary or artificially sweetened drinks raises risk of metabolic liver disease by up to 60%, researchers said.

  • At UEG Week 2025 in Berlin, researchers presented analysis of 123,788 UK Biobank participants showing sugar-sweetened and low- or non-sugar-sweetened beverages are linked to higher MASLD risk.
  • With MASLD affecting over 30% worldwide, researchers investigated low- or non-sugar-sweetened beverages because 'diet' alternatives are often seen as healthier but their liver effects were unclear.
  • A 330 g daily swap for water produced measurable risk reductions, lowering MASLD risk by 14.7% when replacing SSBs and by 12.8% and 15.2% for SSBs and LNSSBs respectively.
  • Over the median 10.3-year follow-up, study authors and clinicians urged limiting both beverage types, with Lihe Liu stating, `The safest approach is to limit both sugar-sweetened and artificially-sweetened drinks. Water remains the best choice as it removes the metabolic burden and prevents fat accumulation in the liver while hydrating the body.`
  • Researchers now aim to explore causal mechanisms through trials, planning long-term randomized and genetic trials focused on the gut microbiome, while Liu described glucose spikes, weight gain, and microbiome changes as possible pathways.
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Artificially sweetened and sugary drinks both increase liver disease risk

Scientists say the safest approach is to limit both sugar-sweetened and artificially sweetened drinks.

The dangers of sodas Sodas are also present in our refrigerators, without any real knowledge of the dangers of excessive consumption. Containing a high amount of sugar, drinking this type of drink daily can cause many health concerns such as diabetes, obesity or cardiovascular diseases. If the "light" or "sugar-free" versions of these drinks are sold as a better alternative to our health, we quickly realize by looking at their compositions that …

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Medical Xpress broke the news in on Monday, October 6, 2025.
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